还没做过化疗，EGFR是野生型的病友一定要去做ALK的检测

jzjqian 发表于 2012-7-25 15:45

" S6 i' G' p7 r$ L                               
登录/注册后可看大图

请教，像我这样的，手术22个月了，还能去原手术医院拿到病理作EGFR检查么？

5 z& w# i& l& c7 ^6 S可以，但要有针对性，

请问，肺鳞癌，只做过一次化疗，骨髓抑制严重，后吃特罗凯4个月基本无效，可以参加实验组吗？

不可以了,要没做过任何治疗的,包括化疗和靶向药

Concomitant EGFR mutation and EML4-ALK gene fusion in non-small cell lung cancer.  Print this page  

. F! ~, X. j' r0 a+ @
Sub-category:
Molecular Targets

2 |" {! ]& B4 y0 {0 L* D: l, x
' `2 F+ ~7 N+ }7 QCategory:
Tumor Biology
) w/ A5 w( p: e! Y& E. f+ r

Meeting:
' H2 A7 Y+ _6 q6 W. B/ o2011 ASCO Annual Meeting
5 A+ U7 Z% S& }7 I" A- J) A
5 x% v, _8 P' r( L, f
Session Type and Session Title:
, V5 S/ x& P7 M+ V* ^1 dPoster Discussion Session, Tumor Biology
6 K. M# x$ L; E8 t* o- Y

5 a8 ?* v; _  e) v2 D5 c  UAbstract No:
10517

; n3 _  N1 F8 e$ j
Citation:
2 y# N+ R' d$ q7 X7 X9 rJ Clin Oncol 29: 2011 (suppl; abstr 10517)


Author(s):
. r1 U  f: Q: dJ. Yang, X. Zhang, J. Su, H. Chen, H. Tian, Y. Huang, C. Xu, Y. L. Wu; Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China; Guangdong Lung Cancer Institute, Medical Research Center of Guangdong General Hospital, Guangzhou, China; Guangdong Lung Cancer Institute, Guangzhou, China; Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China

1 \! f( {, ]5 j0 L

$ U$ [0 j# _$ p5 B) }: c8 X; C4 `Abstracts that were granted an exception in accordance with ASCO's Conflict of Interest Policy are designated with a caret symbol (^) here and in the printed Proceedings.

Abstract Disclosures
) ]7 ~7 s0 j6 D* |
Abstract:
7 a' _0 D" s4 k" K" M
- ^4 t# A& K9 q2 h- O
: N: Y+ @0 `3 j: q& a" M3 PBackground: The fusion of the anaplastic lymphoma kinase (ALK) with the echinoderm microtubule-associated protein-like 4 (EML4) and epidermal growth factor receptor (EGFR) mutations are considered mutually exclusive. Advanced non-small cell lung cancer (NSCLC) patients with EML4-ALK did not benefit from EGFR tyrosine kinase inhibitors (TKIs). Methods: Multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) followed by sequencing was performed for EML4-ALK fusion status detection. EGFR and KRAS mutations were determined by direct DNA sequencing. Positive results of EML4-ALK fusion were also confirmed by RACE-coupled PCR sequencing. Results: From April 2010 to January 2011, 412 patients (398 with NSCLC; 14 with SCLC) were tested for mutation status of EGFR, KRAS and EML4-ALK respectively. Frequency of EML4-ALK fusion was 10.6% (42/398) in NSCLC patients. No patients with SCLC were found to have positive EML4-ALK fusion. Frequency of concomitant EGFR and EML4-ALK gene mutations was 1.0% (4/398) in NSCLC patients, and their variants of EML4-ALK gene mutations were Variant 1 (3 patients) and Variant 6 (1 patient); being never smokers, all of them were diagnosed with advanced (3 with stage †W and 1 with stage IIIB) adenocarcinoma harbouring wild type KRAS. Two female stage †W patients with double gene mutations (1 with L858R and Variant 1; 1 with exon19 deletion and Variant 6) received first-line gefitinib which is one kind of EGFR TKIs and achieved partial response. Conclusions: Though being rare events, NSCLC patients harbouring concomitant EGFR mutation and EML4-ALK gene fusion are sensitive to first-line EGFR TKIs. Whether they could also benefit from ALK inhibition after failure to EGFR TKIs warranted further investigation.
! z5 W0 @, G1 V7 b' Z
  u/ U9 r8 S2 Y. e

由吴一龙教授牵头的A80810029临床试验上周启动，初诊未治疗的晚期肺腺癌患者检测到ALK阳性，可参加一线crizotinib 对比力比泰+卡铂的临床研究，药物全部免费，即使分配到力比泰组，疾病进展之后可免费获得crizotinib.

没有手术，只化疗过，现吃靶向药，未突变，alk未测，有机会入组吗？

boeun 发表于 2012-11-18 16:37

                               
登录/注册后可看大图

4 X& h3 z! s& W7 ~# A没有手术，只化疗过，现吃靶向药，未突变，alk未测，有机会入组吗？

; a0 G+ ^' }7 ~  h+ N& h化疗过的没机会了

平安！ 发表于 2012-7-20 11:20

& s1 v9 C/ e6 O4 V8 D                               
登录/注册后可看大图

) F* x0 B, w& Y- C6 |: ^1 j易瑞沙、特罗凯有效的病人基本上可以断定ALK（-）。极其罕见EGFR、ALK同时突变的。
6 I1 y5 f. W8 F& q: YALK一个指标医院要900多 ...

8 \+ _% L3 F% M# J1 D/ t) Q平安，真的没有希望吗？我弟弟虽然特罗凯有效，但是ＥＧＦＲ是野生型，不是突变啊。有没有必要去检测ＡＬＫ呢？
+ i4 b3 I) ]- N0 Y' Y% Z. ~
现在病情进展，快没招儿了。

好像想加入挺困难的

小地方没条件做啊