发给老马备查:7 v& @& n6 x; W+ a1 {/ V+ {
滴水察海(69304838) 15:23:23. B. \8 i9 |4 A5 B/ r
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
5 n# k6 B9 f, X9 c0 x/ j2 h- ^吉非替尼和S-1连用的依据 b2 H I0 X( O$ E9 ~ |( U
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
' ~5 f1 l9 _' d) S4 l是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
& o) L7 o @# I: s8 R2 }3 Z: c这样是不是推理出,耐药后,可以用S-1和培美了?
3 e( u2 Z/ x8 K; H( z6 u# R- W0 }( K/ s结论:
5 G2 C& N6 X$ c2 Z如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |