发给老马备查:
, L3 [: r- z4 ~滴水察海(69304838) 15:23:233 h0 e1 r7 g$ h+ d4 d- I/ x2 `
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
4 f5 Q: ?- S |" h吉非替尼和S-1连用的依据- {6 C! G* J6 Y+ j& e) t/ g5 \
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.# X$ U y% {& p* T4 U$ C# N7 I
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达3 U3 `8 ]& J; ~( A, M* h
这样是不是推理出,耐药后,可以用S-1和培美了?
0 S' i, {! a# b3 q, F4 I结论:* b# L$ @. Y/ [& i r
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |