看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。: O; ?& l5 E- Q2 Z1 @) x
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! ^8 R! t4 M8 ^ Y- _, |Currently available feasibility data for possible combination strategies. ) ^' R) `% v: a- ?
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& u, V1 w a. A$ V JCombination Feasibility according to preliminary data $ F7 L: M. f: }# d2 |% q! c
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Bevacizumab + sorafenib Yes, reduced dose
* W* u( x! O0 f3 Y1 M# F. \Bevacizumab + sunitinib† No
4 ^9 B- j; s7 f, q" jBevacizumab + temsirolimus Yes + Q( @$ G9 N9 a
Bevacizumab + everolimus Yes 8 [( R; J& p8 e* I7 A# [! n
Sorafenib + sunitinib ?
5 B C X( S( l, hSorafenib + temsirolimus Yes, reduced dose
/ I/ H0 P3 _0 mSorafenib + everolimus Yes, reduced dose
* D8 B1 |% _! O* p; w q: ESunitinib + temsirolimus† No
/ o N2 U( ]# B/ l4 USunitinib + everolimus ?
8 S" O0 u* r9 K1 ], m. PTemsirolimus + everolimus ? ( B- g$ K7 @7 F- T- S( Y
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†Led to US FDA warning.
2 \1 C; W2 I& `# ~9 r4 N, H; ~?: As yet unattempted combination.
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