Last, consistent with our previous preclinical studies, 18 an up-regulation of genes related to cellular adhesion, extracellular matrix disassembly, and angiogenesis, mechanisms of invasion and metastases in METex14 were also up-regulated in our METex14 cohort by pathway analysis. Tumor angiogenesis is hypothesized to promote an immunosuppressive environment 45 and may serve as an additional factor in immunotherapy resistance in METex14. ...
这是为何越来越多医生开始对MET靶向药化疗以及免疫加上抗血管生成药的原因
Molecular dynamic simulations revealed that ensartinib exhibited favorable binding to c-MET. Ensartinib was highly effective in inhibiting the kinase activity of the MET exon 14 deletion protein (IC50 = 7.9 nM). Furthermore, ensartinib potently suppressed the MET pathway and the growth of Hs746T cells that were subcutaneously implanted into mice. Most importantly, of 17 patients with 14 different types of MET exon 14 skipping mutations undergoing ensartinib treatment, 1 (6%) showed a complete response, 11 (65%) achieved a partial response, and 4 (24%) exhibited stable disease. Thus, the objective response rate (ORR) was 71% and the disease control rate (DCR) was 94%, and the ORR in MET-TKI naive patients was even higher (12/15, 80%). In 2 patients with brain metastasis without prior brain radiation, we observed one partial response in the brain, while in the other patient the brain lesions were stable for 6 months. The most frequently reported adverse events were rash, peripheral edema, and nausea; however, no fatal adverse events occurred.
再次看到恩沙替尼
MET inhibition enhances the effect of radiation in MET mutated non-small cell lung cancer brain metastasis patient derived xenograft
简单翻译 脑转移放疗 280别停
吕超 发表于 2022-09-16 06:11
前3后2像不像 ？ NF1？
期待好消息https://majia.yuaigongwu.com/public/emotion/face_075.png
前3后2像不像 ？NF1？
http://oss.yuaigongwu.com/pic/20220916/1663279748889365184.jpg
http://oss.yuaigongwu.com/pic/20220916/1663279748897841348.jpg
http://oss.yuaigongwu.com/pic/20220916/1663279774643162821.jpg
http://oss.yuaigongwu.com/pic/20220916/1663279843566776282.jpg
http://oss.yuaigongwu.com/pic/20220916/1663279843937493325.jpg
吕超 发表于 2022-09-15 15:10
新的计划 初探
280+曲美替尼
These results indicate that significant intertumoral heterogeneity exists within the NF1-P53 and NF1 tumorgrafts that promote resistant to MET inhibition. In comparison, NF1-related MPNSTs with high MET expression and activity (i.e. NF1-MET), significant efficacy of MET inhibition was consistently observed。
关键词 NF1-MET，NF1-tp53
吕超 发表于 2022-09-15 15:10
新的计划 初探
280+曲美替尼
NF1基因突变可能导致RAS/RAF/MEK/ERK信号途径失调，而这可能导致细胞以不受控制的方式生长、分裂和复制，并可能导致肿瘤生长。曲美替尼通过抑制这条途径中的MEK酶，潜在地抑制肿瘤生长。
新的计划 初探
280+曲美替尼
http://oss.yuaigongwu.com/pic/20220915/1663225658541243115.jpg
http://oss.yuaigongwu.com/pic/20220915/1663225692249467204.jpg
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http://oss.yuaigongwu.com/pic/20220915/1663225732466927297.jpg
http://oss.yuaigongwu.com/pic/20220915/1663225812224512671.jpg
关于MET ，如果克唑替尼有效，因为副作用而不得不换280或赛沃无效的，可以试试ALK药，有时候ALK不一定一次检测出来。
吕超 发表于 2022-9-8 22:23
群里一个1230C 患友 全身多部位进展，用培美+K 已经稳定了4-5次，深深吸引了我。 免疫副作用并不一定比184 ...
不知道你看了DAN的免疫治疗经历了么？大包给他家的治疗经验做了总结，我几个月前问过他，效果很好，跟常人一样